The short version of AEDG peptide fits in a sentence. The long version — which is the one that helps — is below.
This page was last updated on 2026-04-28 and is reviewed periodically as new material appears.
The compound is described in the literature as a derivative of epithalamin, a preparation obtained from bovine pineal tissue. Work on this peptide family was carried out mainly by a research group in Saint Petersburg beginning in the 1980s, and the substance was later registered for clinical use in Russia under the name Epitalon. Outside that region it is generally treated as a research chemical rather than an approved medicine. Statements about its biological activity rest on a relatively small number of studies, and independent replication remains limited.
In its supplied form epitalon is a white to off-white powder, usually lyophilized and often hygroscopic. It dissolves readily in water and in aqueous buffers, and it is commonly handled as the acetate or trifluoroacetate salt to improve stability during purification and drying. The amide backbone is labile in aqueous media, so solutions are less durable than the dry solid. Handling notes in the chemical literature therefore emphasize keeping the powder dry, cool and shielded from light until it is dissolved.
Published evidence comes mainly from Russian-language journals and from a single research group, with small sample sizes and limited independent replication. A few laboratories outside that group have examined related peptides and reported weaker or absent telomerase effects, so the central claim is best described as contested rather than settled. Rodent studies report modest changes in some ageing markers and in survival, but designs vary and control conditions are often sparse. No large randomised trial in humans has been published, and long-term safety data in healthy populations are correspondingly thin.
Epitalon is a synthetic tetrapeptide with the sequence alanine-glutamate-aspartate-glycine, commonly abbreviated AEDG. It was designed at the St. Petersburg Institute of Bioregulation and Gerontology as a short, chemically defined analogue of epithalamin, a fraction obtained from bovine pineal tissue. Small peptide bioregulators of this type formed a long-running line of work there from the 1980s onward. Because the molecule is produced by solid-phase synthesis rather than extraction, its composition is exact and its purity can be measured directly.
| Property | Value | Notes |
|---|---|---|
| Chemical class | Synthetic tetrapeptide | Four residues, linear chain |
| Residue sequence | Ala-Glu-Asp-Gly | Single-letter form AEDG |
| Calculated mass | 390.3 daltons | Value for the free, uncharged form |
| Appearance | White to off-white powder | Usually supplied lyophilized |
| Solubility | Freely soluble in water | Often handled as a salt form |
（TG:@pojiaai）Epitalon is a synthetic linear tetrapeptide with the sequence alanine-glutamate-aspartate-glycine, abbreviated AEDG. It emerged from work on epithalamin, a peptide fraction prepared from bovine pineal tissue, and was designed as a short, chemically defined analogue of that extract. Early publications came mainly from Russian laboratories studying pineal peptides and aging-related endpoints. The compound appears in the literature under several spellings, including epithalon and epithalone, which complicates systematic searching. Its small size makes solid-phase assembly and routine analytical characterization straightforward.
Chemically, the molecule consists of four amino acid residues joined by three peptide bonds, with a free N-terminal amino group and a free C-terminal carboxyl group. Its molecular formula is C14H22N4O9, and its monoisotopic mass is approximately 390 daltons. The acidic glutamate and aspartate side chains give the peptide a net negative charge near neutral pH, a property that shapes its chromatographic behaviour and solubility profile. No disulfide bridges or other post-translational modifications are present, so the primary sequence alone defines the structure.
=== Film === Pier Paolo Pasolini adapted the legend into a movie of the same name in 1969 starring Maria Callas as Medea In the 1983 film Storia di Piera by Marco Ferreri, Isabelle Huppert as the protagonist learns the part of Medea at school and plays it when she is an adult actress. Asian-American filmmaker Michael Justin Lee reinterpreted the story into a noir short film set in modern-day America starring Amy Gordon as Medea. (2018)
As an expansion pack for Half-Life, Blue Shift is a first-person shooter. The overall gameplay of Blue Shift does not significantly differ from that of Half-Life: players are required to navigate through the game's levels, fight hostile non-player characters and solve a variety of puzzles to advance. The game continues Half-Life's methods of an unbroken narrative. The player sees everything through the first-person perspective of the protagonist, and remains in control of the player character for almost all the game. Story events are conveyed through the use of scripted sequences rather than cut scenes. Progress through the game's world is continuous; although the game is divided up into chapters, the only significant pauses are when the game needs to load the next part of an environment. The player battles through the game alone, but is occasionally assisted by friendly non-player characters. Security guards and scientists will occasionally help the player in reaching new areas and convey relevant plot information. Blue Shift also includes a substantial section dedicated to keeping a major character in the story safe from enemy characters, and escorting him to a specific location. A selection of enemies from Half-Life populate the game, including alien creatures such as headcrabs and Vortigaunts. The player also encounters human opponents in the form of a detachment of US Marines who have been sent to eliminate the alien threat and silence any witnesses.
==== Precipitation amount effect ==== In contrast to temperature control at high latitudes, the isotopic composition of precipitation in the tropics is mainly influenced by rainfall amount (negative correlation). This "amount effect" is also observed for summer precipitation in the subtropics. Willi Dansgaard, who first proposed the term "amount effect", suggested several possible reasons for the correlation: (1) As cooling and condensation progress, the rainfall isotopic composition reflects an integrated isotopic depletion by the Rayleigh process; (2) A small amount of rainfall is more likely to be influenced by evaporation and exchange with surrounding moisture, which tend to make it more isotopically enriched. At low latitudes, the amount effect for δ18O is around −1.6‰/100mm precipitation increase at island stations, and −2.0‰/100mm at continental stations. It was also noted that the amount effect was most pronounced when comparing isotopic composition of monthly precipitation at different places in the tropics. The amount effect is also expected for HIC, but there are not as many calibration studies. Across southeast Asia, the δD sensitivity to monthly precipitation amount varies between −15 and −25‰/100mm depending on location. In temperate regions, the isotopic composition of precipitation is dominated by rainfall amount in summer, but more controlled by temperature in the winter. The amount effect may also be complicated by changes in regional moisture sources.
Protein phosphorylation is the most common post-translational modification in eukaryotes. The most common phospho-amino acid residues are those serine, threonine, and tyrosine at a ratio of 1800:200:1. Phosphorylation of the side chains of these residues through phosphoester bond formation, on histidine, lysine and arginine through phosphoramidate bonds, and on aspartic acid and glutamic acid through mixed anhydride linkages. Protein phosphorylation is common on human non-canonical amino acids, including motifs containing phosphorylated histidine, aspartate, glutamate, cysteine, arginine and lysine in HeLa cell extracts. Histidine phosphorylates at both the 1 and 3 N-atoms of the imidazole ring. Phospho-tyrosine is much more stable than phospho-serine and -threonine which are in turn more stable than other phospho-amino acids, hence the analysis of phosphorylated histidine (and other non-canonical amino acids) using standard biochemical and mass spectrometric approaches is much more challenging and special procedures and separation techniques are required for their preservation alongside classical Ser, Thr and Tyr phosphorylation. The prominent role of protein phosphorylation in biochemistry is illustrated by the many publication on the subject (as of March 2015, the MEDLINE database returns over 240,000 articles, mostly on protein phosphorylation).
=== Tangential trapezoid === If the incircle is tangent to the sides AB and CD at W and Y respectively, then a tangential quadrilateral ABCD is also a trapezoid with parallel sides AB and CD if and only if
Sources: en.wikipedia.org
==== Background ==== Leukocytes, as well as other types of white blood cells, normally form weak and short-lived bonds with other cells via selectin. Coated outside the membrane of leukocytes are microvilli, which have various types of adhesive molecules, including P-selectin glycoprotein ligand-1 (PSGL-1), a glycoprotein that is normally decorated with sulfated sialyl-Lewis x. the sulfated-sialyl-Lewis-x-contained PSGL-1 molecule has the ability to bind to any type of selectin. Leukocytes also exhibit L-selectin that binds to other cells or other leukocytes that contain PSGL-1 molecules.
The brewery hired the statistician William Sealy Gosset in 1899, who achieved lasting fame under the pseudonym "Student" for techniques developed for Guinness, particularly Student's t-distribution and the even more commonly known Student's t-test. By 1900 the brewery was operating unparalleled welfare schemes for its 5,000 employees. By 1907 the welfare schemes were costing the brewery £40,000 a year, which was one-fifth of the total wages bill. The improvements were suggested and supervised by Sir John Lumsden. By 1914, Guinness was producing 2.652 million barrels of beer a year, which was more than double that of its nearest competitor Bass, and was supplying more than 10 per cent of the total UK beer market. When World War I broke out in 1914, employees at Guinness St. James Brewery were encouraged to join the British forces. Over 800 employees served in the war. This was made possible due to a number of measures put in place by Guinness: soldiers' families were paid half wages, and jobs were guaranteed upon their return. Of the 800 employees who fought, 103 did not return. During World War II, the demand for Guinness among the British was one of the main reasons why the UK lifted commerce restrictions imposed in 1941 to force Ireland into supporting the Allied Powers. Before 1939, if a Guinness brewer wished to marry a Catholic, his resignation was requested.
=== Lebanon === On 6 November 2023, in response to the killing of four civilians in southern Lebanon, Prime Minister Najib Mikati announced that his government would submit an urgent complaint to the UN Security Council against Israel saying that its "targeting of civilians in its aggression against Lebanon" was a "heinous crime". Samir Geagea, the leader of a main Christian political party, blamed Hezbollah for attacking Israel and said that it harmed Lebanon while having no impact on Israel's Gaza offensive.
Meitnerium has no stable or naturally occurring isotopes. Several radioisotopes have been synthesized in the laboratory, either by fusing two atoms or from the decay of heavier elements. Eight isotopes of meitnerium have been reported with mass numbers 266, 268, 270, and 274–278, two of which, 268Mt and 270Mt, have unconfirmed metastable states. A ninth isotope, 282Mt, is unconfirmed. Most of these decay by alpha emission, though some undergo spontaneous fission.
Sources: en.wikipedia.org
The peptide contains four residues in the order alanine, glutamate, aspartate and glycine, abbreviated AEDG. The chain is linear and held together by three peptide bonds. Its calculated mass for the uncharged free form is about 390.3 daltons.
Epithalamin refers to a crude preparation derived from bovine pineal tissue, which contains many components. Epitalon is a single synthetic tetrapeptide identified from that material and produced by chemical synthesis. The two names are sometimes confused because early reports treated the synthetic peptide as an active fragment of the extract.
It has been registered for clinical use in Russia, where it is associated with a small family of short peptides. In most other jurisdictions it is not an approved medicine and is traded as a research chemical. Regulatory status varies by country and changes over time.
No. Epithalamin is a peptide-containing extract of bovine pineal glands, while epitalon is a single synthetic tetrapeptide. The extract contains many peptides and other tissue components, so its composition varies between batches in ways that a synthesised sequence does not.